A Major Step Forward in Sustainable Crop Protection

AGRO4AGRI has reached an important scientific milestone with the completion of M4: Selection of the most lethal gene targets for the development of innovative, Safe and Sustainable by Design (SSbD) nematicides. This achievement strengthens the project’s progress toward delivering precise and environmentally friendly solutions to control plant parasitic nematodes.

Towards Next Generation, Target-Specific Nematicides

Under WP4, partners are exploring interference RNA (RNAi)-based strategies capable of disabling essential nematode functions. By analysing a broad list of candidate gene sequences, the consortium identified those that show the strongest potential to weaken or prevent nematode attacks on crops such as tomato and watermelon.

Despite biological and technical challenges, including nematode growth timing and the need to ensure RNA stability, partners worked closely to ensure every step remained aligned with SSbD principles and real agricultural needs.

Promising Gene Targets Identified

Through this collaborative effort, AGRO4AGRI has now selected the most effective gene targets for ongoing laboratory and formulation work. This milestone enables the project to advance into the next development phase.

Driving Impact Through Sustainable Innovation

The achievement of Milestone 4 marks a significant advance for WP4 and the entire project. It confirms AGRO4AGRI’s commitment to developing precise, sustainable and farmer-relevant nematode control tools, reinforcing European leadership in responsible agricultural innovation.

For additional background on RNA interference and its potential in sustainable pest control, consult this external article (available only in Spanish).